Objective: To evaluate the reliability and validity of the Chinese version of Morisky medication adherence scale (MMAS-8) in children with nephrotic syndrome (NS)

and to explore the medication adherence level and influencing factors of children with NS in this region. Methods: The Chinese version of MMAS-8 was used to investigate the medication adherence of 90 children with NS in our hospital. Cronbach α coefficient was used to evaluate the internal consistency reliability of the Chinese version of MMAS-8

the intra-group correlation coefficient (ICC) was used to evaluate the test-retest reliability

the principal component factor analysis method was used to evaluate the structural validity. Pearson correlation coefficient was used to evaluate the correlation between MMAS-8 score and the number of recurrences within 6 months. Influencing factors of medication adherence in children with NS were analyzed by multi-factor ordered multi-class Logistic regression. Results: The Cronbach α coefficient of the Chinese version of MMAS-8 was 0.751

the ICC was 0.865 (P<0.05). Three common factors were extracted by principal component factor analysis

78.89% of the 90 children surveyed had poor medication adherence (<8 points). There was moderate negative correlation between the number of recurrences within 6 months and the score of MMAS-8 (Pearson correlation was -0.454

P<0.01). Results of influencing factors of medication adherence showed that children with disease course less than 1 year had better medication adherence than those with the course of disease more than 3 years (P<0.05)

children with parental supervision had better medication adherence than those with self-medication (P<0.05)

and the more the children and their families knew about the disease

the better the medication adherence (P<0.05). Age

gender and number of recurrences had no statistical significance on medication adherence (P>0.05). Conclusion: The Chinese version of MMAS-8 has good reliability and validity

and can be used to assess the medication adherence of children with NS. The level of medication adherence of children with NS in this area is not high

which is related to the course of disease

guardian of medication and basic knowledge of the disease.